논문투고-심사위원수정

대한임상미생물학회

   접수번호

  20150023

   접수일

  2015-08-10

   구분

  원저

   교신저자

  강정옥        (rearview : 성흥섭)

   소속

  한양의대 진단검사의학과

   이메일

  jokang@hanyang.ac.kr

   제목

  호흡기 바이러스 검출을 위한 Nasopharyngeal aspirate 검체와 Nasopharyngeal flocked swab 검체의 비교

   Running Title

  

   영문초록

  Background: Nasopharyngeal aspirate (NPA) is known as the best specimen for the accurate diagnosis of viral respiratory infections in pediatric patients, but the procedure is very annoying. Recently introduced flocked swabs have been reported easy to obtain good quality specimen and comfortable to the patients. The purpose of this study was to compare the sensitivities among NPA and nasopharyngeal flocked swabs (NPFS) for the detection of respiratory viruses in children.
Methods: One hundred eleven hospitalized children under 12-year-old with acute respiratory tract infections were recruited. NPA and NPFS were obtained in parallel from each patient. NPFS were always collected after NPA. Specimens were tested in triplicate by indirect immunofluorescence (IIF) method, viral cultures, and multiplex PCR.
Results: The proportion of inadequate specimens for IIF method was higher in NPA (23.4%) than NPFS (5.4%). According to the consensus positive, the positive rates of NPFS were higher than those of NPA (45.7% and 30.6% by IIF method; 37.8% and 27.9% by culture; 67.6% and 55.9% by multiplex PCR).
Conclusion: The higher sensitivity of the NPFS specimens for IFF and virus culture could make them an alternative to NPA samples. But careful quality control, expertise training, and adherence to procedure manual will be needed to get more accurate results for each detection methods.

   Key Words

  Respiratory Viruses, Respiratory Specimen Collectio, Nasopharyngeal Aspirate, Nasopharyngeal Flocked Swab

   논문파일

1 . 표지(Title Page) A-20150023-1-00.docx 35 Kbytes 2015-08-10
2 . 본문(Main Body) A-20150023-2-00.docx 93 Kbytes 2015-08-10
3 . 본문(Main Body) 1차 수정 A-20150023-2-01.docx 116 Kbytes 2015-09-21
4 . 표지(Title Page) 2차 수정 A-20150023-1-02.docx 34 Kbytes 2015-10-13
5 . 본문(Main Body) 2차 수정 A-20150023-2-02.docx 119 Kbytes 2015-10-13
6 . 표지(Title Page) 3차 수정 A-20150023-1-03.docx 34 Kbytes 2015-10-22
7 . 본문(Main Body) 3차 수정 A-20150023-2-03.docx 119 Kbytes 2015-10-22
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1 신수 jeannie@snu.ac.kr Y 010-3052-7110 Y 2015-08-31 2015-09-01 수정후 재심사
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