논문투고-심사위원수정

대한임상미생물학회

   접수번호

  20150031

   접수일

  2015-11-10

   구분

  원저

   교신저자

  박연준        (chjulia : 장지영)

   소속

  서울성모병원

   이메일

  yjpk@catholic.ac.kr

   제목

  한국인 가임기여성에서 Ureaplasma species 의 빈도와 항생제감수성 : 유전자 변이와의 일치

   Running Title

  

   영문초록

  Background : While the pathogenicity of U. urealyticum is known, that of U. parvum is controversial. We investigated the prevalence and drug resistance of Ureaplasma species in Korean women of reproductive age.
Methods : This study included 151 cultured specimens in Seoul St. Mary hospital between October and November 2014. Specimens were screened with Mycoplasma IST2 kit (bioMérieux, France) and the antimicrobial susceptibilities were determined. The identification of Ureaplasma species was performed by PCR. In addition, mutation of drug resistance gene was investigated by sequencing.
Results : The positive rate of Ureaplasma and Mycoplasma hominis was 43.7%(66/151). Of the 66 samples, 53 (80.4%) were identified as U. parvum ; 5 (7.6%) as U. urealyticum ; 2 (3.0%) as M. hominis ; 6 (9.0%) as mixed infection. Susceptibilities of Ureaplasma spp to erythromycin, azithromycin, clarithromycin and doxycycline were 84.5%, 79.3%, 98.3% and 94.8%, respectively. The susceptibility of Ureaplasma spp to ofloxacin and ciprofloxacin was 47.4% and 27.5%, respectively. The S83L mutation was found in the ParC subunit of the ofloxacin-resistant (5/7,71.4%) and the ciprofloxacin-resistant isolates (7/14,50.0%).
Conclusion : The rate of isolation of genital mycoplasma in Korean women of reproductive age was 43.7% ; most of the mycoplasma was identified as U. parvum. As more than 10% of Ureaplasma species showed non-susceptibility to erythromycin and azithromycin, susceptibility test is needed to use these antibiotics. Further study is needed about the clinical features of infections caused by U. urealyticum vs U. parvum and resistance mechanisms.

   Key Words

  U. urealyticum, U. parvum, Mycoplasma IST2 kit, antimicrobial susceptibility

   논문파일

1 . 표지(Title Page) A-20150031-1-00.docx 17 Kbytes 2015-11-10
2 . 본문(Main Body) A-20150031-2-00.docx 57 Kbytes 2015-11-10
3 . 국문초록 A-20150031-4-00.docx 19 Kbytes 2015-11-10
4 . 표지(Title Page) 1차 수정 A-20150031-1-01.docx 17 Kbytes 2016-01-10
5 . 본문(Main Body) 1차 수정 A-20150031-2-01.docx 69 Kbytes 2016-01-10
6 . 국문초록 1차 수정 A-20150031-4-01.docx 19 Kbytes 2016-01-10
7 . 표지(Title Page) 2차 수정 A-20150031-1-02.docx 17 Kbytes 2016-01-27
8 . 본문(Main Body) 2차 수정 A-20150031-2-02.docx 75 Kbytes 2016-01-27
9 . 국문초록 2차 수정 A-20150031-4-02.docx 20 Kbytes 2016-01-27
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1 어영 u931018@yonsei.ac.kr Y 010-5361-9013 Y 2015-11-30 2015-12-03 수정후 재심사
1 성흥섭 sung@amc.seoul.kr Y 010-2695-4498 Y 2015-11-30 2015-11-27 수정후 편집위 결정
1 이혁민 hmlee.labmed@gmail.com Y 010-9414-8155 Y 2015-12-03 2015-12-22 수정후 편집위 결정
2 어영 u931018@yonsei.ac.kr Y 010-5361-9013 Y 2016-01-25 2016-01-12 수정후 편집위 결정

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1 Y 2015-12-28 2015-12-28 결과수정
2 Y 2016-01-14 2016-01-14 결과수정

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1 2016-01-10 결과보기
2 2016-01-27 결과보기