논문투고-심사위원수정

대한임상미생물학회

   접수번호

  20180019

   접수일

  2018-08-10

   구분

  원저

   교신저자

  김인숙        (iskim0710 : 김인숙)

   소속

  양산부산대학교병원

   이메일

  iskim0710@gmail.com

   제목

  강력한 항레트로바이러스 치료를 받는 한국인 HIV 환자에 있어 기회 감염과 IL10 유전 변이와 일배체형과의 영향 분석

   Running Title

  

   영문초록

  INTRODUCTION; Genetic variants and haplotypes of Interleukin 10 (IL10) have been shown to affect clinical outcomes including opportunistic infections (OIs) in the HIV-infected patients. This study investigated the effect of IL10 gene on susceptibility to OIs among HIV-infected Korean patients in the era of highly active antiretroviral therapy (HAART).
METHODS: Eighty-five HIV-infected patients receiving HAART were enrolled. OIs were diagnosed from published criteria of the Korean Society for AIDS. Three promoter SNPs and four haplotype-tagging SNPs (htSNPs) of IL10 were selected and genotyped. The haplotypes were reconstructed according to the genotyping data and the linkage disequilibrium (LD) status of these SNPs.
RESULTS: Among the 85 HIV-infected patients, 38 OIs developed in 23 patients (27.1%), a rate of 1.7 episode/patient. The patients carrying the minor alleles in rs1518111, rs3024490, and rs1800871 showed the protective effect of OIs (adjusted P = 0.035). These seven variants showed only three possible haplotypes were demonstrated. The second most common haplotype, which were composed of the minor allele of rs1518111 and the major allele of rs3021094, showed a protective effect on OIs (P = 0.0153).
CONCLUSIONS: This study demonstrates that some IL10 genetic variants and haplotypes are associated with protective effects on OIs in the era of HAART. This data suggests the informative marker set of two htSNPs with rs1518111 and rs3021094 to reveal genetic association of IL10 in Koreans. This is the first report on the association of IL10 gene with OIs in HIV-infected Korean patients in the era of HAART.

   Key Words

  Opportunistic infections, HIV, Susceptibility, Haplotype, IL10

   논문파일

1 . 표지(Title Page) A-20180019-1-00.docx 16 Kbytes 2018-08-10
2 . 본문(Main Body) A-20180019-2-00.docx 187 Kbytes 2018-08-10
3 . 국문초록 A-20180019-4-00.docx 16 Kbytes 2018-08-10
4 . 표지(Title Page) 1차 수정 A-20180019-1-01.docx 16 Kbytes 2018-11-21
5 . 본문(Main Body) 1차 수정 A-20180019-2-01.docx 214 Kbytes 2018-11-21
6 . 국문초록 1차 수정 A-20180019-4-01.docx 16 Kbytes 2018-11-21
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1 성흥섭 sung@amc.seoul.kr Y 010-2695-4498 Y 2018-08-27 2018-08-18 수정후 편집위 결정
1 김현수 hskim0901@empas.com Y 010-8996-0901 N 2018-08-27
1 김한성 kimhan@hallym.ac.kr Y 010-2285-7494 Y 2018-08-27 2018-09-11 수정후 편집위 결정
1 김택수 kim.taeksoo@outlook.com Y 010-2820-0309 Y 2018-10-04 2018-11-14 게재가

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