논문투고-심사위원수정

대한임상미생물학회

   접수번호

  20180028

   접수일

  2018-11-14

   구분

  원저

   교신저자

  박선희        (psh0215 : 박선희)

   소속

  부산광역시 보건환경연구원

   이메일

  psh0215@korea.kr

   제목

  부산지역 설사환자에서 분리한 Campylobacter jejuni의 항균제 감수성과 유전자형 분석

   Running Title

  

   영문초록

  Background : Campylobacter jejuni is one of the important food-borne pathogen causing human gastroenteritis. This study was conducted to investigate the incidence of isolation, antimicrobial susceptibility pattern and the genotyping of C. jejuni from diarrhea patients in Busan.
Methods : A total of 97 C. jejuni were isolated from diarrhea patients and 5 food-borne outbreaks from 2014 to September 2017. Antibiotic susceptibility test was conveyed by broth microdilution method for ciprofloxacin (CIP), nalidixic acid (NAL), tetracycline (TET), chloramphenicol (CHL), azithromycin (AZI), erythromycin (ERY), streptomycin (STR), gentamicin (GEN), telithromycin (TEL). And Pulsed Field Gel Electrophoresis (PFGE) was performed to analysis for genotyping.
Results : The isolation rate of C. jejuni was 2.0% for the last 4 years and was increased annually. Antimicrobial resistance rates of C. jejuni were shown to be in order of NAL (90.9%), CIP (89.4%), TET (13.6%), AZI (3.0%), ERY (3.0%) and STR (1.5%). And the proportion of multidrug-resistance was 18.2%, and they commonly contained quinolones (CIP-NAL). Analysis of PFGE patterns of SmaI-restricted DNA of C. jejuni isolates showed 17 clusters and cluster 11 was the major genotype pattern.
Conclusion : This study will provide useful data for the proper use of antimicrobials and the management of resistant C. jejuni. Also it will help to accumulate data for the epidemiological investigation of food-borne diseases caused by C. jejuni which is expected to increase in the future.

   Key Words

  Campylobacter jejuni, Antimicrobial susceptibility, PFGE

   논문파일

1 . 표지(Title Page) A-20180028-1-00.docx 16 Kbytes 2018-11-14
2 . 본문(Main Body) A-20180028-2-00.docx 510 Kbytes 2018-11-14
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1 신동훈 shindh@hallym.ac.kr Y -- 2018-12-03
1 신희봉 shinhb@schmc.ac.kr Y 032-621-5942 Y 2018-12-03 2018-12-04 수정후 편집위 결정
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