논문투고-심사위원수정

대한임상미생물학회

   접수번호

  20180029

   접수일

  2018-12-28

   구분

  원저

   교신저자

  김도균        (kyunsky : 김도균)

   소속

  연세대학교 의과대학 진단검사의학과 세균내성연구소

   이메일

  kyunsky@yuhs.ac

   제목

  국내에서 분리된 인체분리균주를 이용한 MicroScan KSCM 패널의 항균제 감수성 시험 분석능 평가

   Running Title

  

   영문초록

  Background: Antimicrobial resistant continues to pose a threat to public health. Therefore, rapid and accurate antimicrobial susceptibility testing is very important. The objectives of this study were to evaluate the performance of the BECKMAN COULTER Microscan system with newly developed KSCM panels for antimicrobial susceptibility testing (AST) against clinical isolates in South Korea.
Methods: Three KSCM panels for AST using Microscan system were designed in this study. For the performance evaluation, a total of 1,325 clinical isolates including 1,027 of Gram-negative bacilli and 298 Gram positive cocci collected from eight general hospitals in South Korea were used. The results by Microscan KSCM panels were compared with those by conventional methods.
Results: By KSCM-1 panel for Gram-positive cocci, the rates of categorical agreement (CA) were > 90% in all the antimicrobials tested in this study. The rates of major errors (MEs) were also < 3%, and only three VME were identified; each of ampicillin, tetracycline, and quinupristin-dalfopristin in enterococcal isolates. By KSCM-2 panel for Enterobacteriaceae, the rates of CA were also above 90%, and those of ME and VME were less than 3% and 1.5%, respectively. KSCM-3 panels for glucose-non-fermenting Gram-negative bacilli, also showed good agreement rates, i.e., CA rates >90%, ME rates <3%, and VME rates <1.5%.
Conclusion: The newly developed three KSCM panels for Microscan system showed excellent performance in AST against a large number of clinical isolates, and they are applicable to clinical microbiology laboratories.

   Key Words

  Microscan, Antimicrobial susceptibility, Evaluation, Performance

   논문파일

1 . 표지(Title Page) A-20180029-1-00.docx 17 Kbytes 2018-12-28
2 . 본문(Main Body) A-20180029-2-00.docx 150 Kbytes 2018-12-28
3 . 이미지(Image File) A-20180029-3-00.pptx 218 Kbytes 2018-12-28
4 . 국문초록 A-20180029-4-00.docx 23 Kbytes 2018-12-28
5 . 표지(Title Page) 1차 수정 A-20180029-1-01.docx 17 Kbytes 2019-03-13
6 . 본문(Main Body) 1차 수정 A-20180029-2-01.docx 156 Kbytes 2019-03-13
7 . 이미지(Image File) 1차 수정 A-20180029-3-01.pptx 2606 Kbytes 2019-03-13
8 . 국문초록 1차 수정 A-20180029-4-01.docx 23 Kbytes 2019-03-13
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